Saying no to drugs: fasting protects hematopoietic stem cells from chemotherapy and aging

Here we present the ‘Abstract‘ of the corresponding paper by Hine C, Mitchell JR.


Aging and chemotherapeutics damage hematopoietic stem cells (HSCs), leading to dysregulation of asymmetric division and subsequent immunosuppression and blood-related diseases. In this issue, Cheng et al. (2014) use prolonged fasting as a medical intervention to decrease IGF-1/PKA signaling and protect HSCs against chemotherapeutic toxicity and promote rejuvenation.


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